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Ranexa produces elevations of serum creatinine by 0.1 mg/dL, regardless of previous renal function, likely because of inhibition of creatinine's tubular secretion. In healthy volunteers, Ranexa 1000 mg twice daily had no effect upon the glomerular filtration rate.
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Angina. Angina is chest pain or discomfort that occurs if an area of your heart muscle does not get enough oxygen-rich blood. This pain can feel like pressure or squeezing in your chest. It also can spread to your shoulders, arms, neck, jaw, or back, just like a heart attack.
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