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Dipeptidyl peptidase-4 inhibitor use in patients with type 2 diabetes and cardiovascular disease or risk factors.

Galvus is already approved in more than 100 countries and Eucreas in over 80 countries.

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Vilsboll T, Krarup T, Sonne J, Madsbad S, Volund A, Juul AG, Holst JJ 2003 Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus.

Having high intraocular pressure increases the risk of developing glaucoma.

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When DPP-4 inhibitors have been used as monotherapy, the incidence of hypoglycaemia was comparable to that of placebo or metformin (around 5%), and a number of randomised controlled trial indicate that this risk is not increased when DPP-4 inhibitors are used in patients treated with metformin or thiazolidinediones, thus confirming their acceptable safety profile.

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Caspary WF, Creutzfeldt W 1971 Analysis of the inhibitory effect of biguanides on glucose absorption: inhibition of active sugar transport.

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The half-life of circulating native bioactive GLP1 is less than 2 min mostly because it is cleared by the kidney and degraded by dipeptidyl peptidase (DPP)-4.

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Since then, there has been an expectation that the FDA would issue some sort of opinion sometime in 2009: for instance, in September, Novo-Nordisk announced that "formal feedback from the United States Food and Drug Administration.

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Dose titration of SU (reduce to half existing dose) is recommended when used along with gliptin or GLP-1 analogue.

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