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Synthroid has relieved most of my hypothyroidism symptoms. I seem to have much more energy during the day and I'm feeling better overall.



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I've been taking Synthroid for almost half a year now to treat hypothyroidism. More than a year ago I had a surgery that resulted in thyroid removal so now I have to keep my hormone level with the help of medications. And Synthroid is the best solution that I have tried out. But before I have found it I had enough time to 'enjoy' all possible symptoms of my post-surgery hypothyroidism. Actually that was closer to being dead than alive and I felt myself correspondingly - like a zombie. I was slow to react, and was almost unable to normally communicate even with my family members. I started losing my hair and that was horrible, now I have to take good care if it to get it back. Luckily due to Synthroid I have enough energy to take care of myself and my hair. I also got a lot of extra weight and now I am trying to follow a healthier diet and get slimmer. But all this is not because of my strong will; it's because of Synthroid that turned me back into a human being. I got my interest in life back! May be it's just a rare case but I have absolutely no side effect with the med. Only positive changes and enthusiasm.

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In a prospective study on 119 consective pregnancies, about 49% of women on l-T 4 replacement therapy had serum TSH outside the reference range (30% had elevated TSH concentrations, and 20% had low TSH concentrations) during the first trimester of pregnancy ().

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Contrary to treatment with a combination of l-T 3 plus l-T 4 or to baseline levels in control healthy subjects, monotherapy with l-T 4 is usually associated with higher FT 4 levels and a higher T 4 to T 3 ratio, especially in hypothyroid patients receiving TSH replacement doses of l-T 4 ().

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To summarize the issue of diagnosis, although hypothyroidism can be suspected by the onset of specific symptoms of thyroid hormone deficiency, it should be specifically confirmed on the basis of results of thyroid function tests.

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Different TSH cutoff levels should be used to define and treat hypothyroidism in children with CoH, in pregnant women, in elderly patients, and in patients with comorbidities.

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The frequency of PTC was closely related to the serum TSH level, being lowest in patients with TSH below the reference range and highest in patients with TSH above the reference range and showing a progressive increase from the lower to the upper quartile of the TSH reference range ().

The risk of HF events was related to higher TSH levels with a statistically significantly increased risk among those with TSH above 10.

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An ongoing study from the United Kingdom, the TABLET (Thyroid Antibodies and l-Thyroxine) study, a multicenter placebo double-blind controlled trial, hopes to clarify the impact of l-T 4 therapy in euthyroid women with positive thyroid autoantibodies planning pregnancy.

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