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Synthroid has relieved most of my hypothyroidism symptoms. I seem to have much more energy during the day and I'm feeling better overall.

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I've been taking Synthroid for almost half a year now to treat hypothyroidism. More than a year ago I had a surgery that resulted in thyroid removal so now I have to keep my hormone level with the help of medications. And Synthroid is the best solution that I have tried out. But before I have found it I had enough time to 'enjoy' all possible symptoms of my post-surgery hypothyroidism. Actually that was closer to being dead than alive and I felt myself correspondingly - like a zombie. I was slow to react, and was almost unable to normally communicate even with my family members. I started losing my hair and that was horrible, now I have to take good care if it to get it back. Luckily due to Synthroid I have enough energy to take care of myself and my hair. I also got a lot of extra weight and now I am trying to follow a healthier diet and get slimmer. But all this is not because of my strong will; it's because of Synthroid that turned me back into a human being. I got my interest in life back! May be it's just a rare case but I have absolutely no side effect with the med. Only positive changes and enthusiasm.

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In a prospective study on 119 consective pregnancies, about 49% of women on l-T 4 replacement therapy had serum TSH outside the reference range (30% had elevated TSH concentrations, and 20% had low TSH concentrations) during the first trimester of pregnancy ().

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Contrary to treatment with a combination of l-T 3 plus l-T 4 or to baseline levels in control healthy subjects, monotherapy with l-T 4 is usually associated with higher FT 4 levels and a higher T 4 to T 3 ratio, especially in hypothyroid patients receiving TSH replacement doses of l-T 4 ().

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Different TSH cutoff levels should be used to define and treat hypothyroidism in children with CoH, in pregnant women, in elderly patients, and in patients with comorbidities.

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The risk of HF events was related to higher TSH levels with a statistically significantly increased risk among those with TSH above 10.

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An ongoing study from the United Kingdom, the TABLET (Thyroid Antibodies and l-Thyroxine) study, a multicenter placebo double-blind controlled trial, hopes to clarify the impact of l-T 4 therapy in euthyroid women with positive thyroid autoantibodies planning pregnancy.

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