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UCLA reported increased pre-cancerous pancreatic changes in rats and in human organ donors who had been treated with DPP-IV inhibitors.

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Though Byetta was recently linked to a tiny number of cases of Pancreatitis (about 6 in hundreds of thousands of people taking the drug) the number of excess cancers attributed to Januvia was much higher per number of people taking the drug than the cases of Pancreatitis.

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Patients with kidney disease should limit protein intake to less than 10% of calories.

Tasigna and Afinitor are in fact ahead of plan, Tasigna going at 33% and Afinitor above 80% growth from last year, and in fact Zometa went down a little bit faster than what we were expecting at the time when we were presenting this number.

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From what I gather, it's the lack of common side effects that accompany use of other oral drugs (sulfonylureas) for Type 2 diabetes, especially weight gain and risk of hypoglycemia.

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Suppressive Effects of Glucose-Dependent Insulinotropic Polypeptide on Cardiac Hypertrophy and Fibrosis in Angiotensin II-Infused Mouse Models.

Another monoclonal antibody called natalizumab brand name Antegren helped Crohns patients in another study.

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This modest HbA1c reduction, and the high cost of this class of drugs, must be factored in when considering this class of drugs for use in patients.

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FDA approves new treatment for Type 2 diabetes.

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Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin.

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It would probably be a very good idea to get your liver enzymes checked every year if you are taking Januvia and if you see any sign that your liver enzymes are rising, get off the drug.

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Some people who took Januvia and Janumet suffered from severe side effects like pancreatitis and pancreatic cancer that may have led to death.

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There's a lot of data that has been accumulated around this concept and we believe it will be a reason to move from Glivec to Tasigna, if you are on Glivec and you don't have a complete molecular response, because Tasigna will be the opportunity to go to the cure and it will be a reason to start with Tasigna if you are newly diagnosed with CML, because it will give you an opportunity in a relatively short period of time around two years to be in a situation without a treatment.

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Longterm followup showed that patients continued to have improvements in their diabetes, as well as a reduction in risk factors for cardiovascular disease, the researchers reported.

None of the pancreases of the people who had had diabetes but had not taken these drugs displayed any of these abnormalities.

If you have been prescribed a gliptin and experience persistent, severe abdominal pain that may sometimes spread to the back, this may be a symptom of acute pancreatitis and you should contact your doctor immediately.

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Healthy eating habits along with good control of blood glucose are the basic goals, and several good dietary methods are available to meet them.

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Drinking black tea may help protect against type 2 diabetes, but more study is needed to confirm an association.

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The manufacturer of Januvia is dismissing this as being due to the population taking Januvia having at least "risk factor" for pancreatitis--diabetes!

Use this medication regularly to get the most benefit from it.

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If necessary the daily dosage can be increased up to 4-6 g, however, the increase of the dosage must be under medical supervision.

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Gliptin (linagliptin) has shown to influence positively macrophage-mediated inflammation response and tissue remodeling, which may have benefits with regard to suppression of vascular inflammation and improvement in wound healing.

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David shared with you some information about the IL-17 blocking molecule, AIN457, the monoclonal antibody we have and I want to take you through some of the biology behind this and why we believe that this offers a potential for differentiation from some of the other treatments that are currently marketed for diseases such as psoriasis.

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