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How long does it take Topamax to work?
Be patient. Although you'll be taking TOPAMAX every day, it may take some time to work. In clinical studies, TOPAMAX was proven to help reduce the frequency of migraines. Some patients experienced fewer migraines after 1 month of treatment; however, it may take 2 to 3 months to realize the full benefit of TOPAMAX.
How does topiramate work in the body?
Topiramate prevents fits by stabilising the electrical nerve activity in the brain. It works in three ways to achieve this. Topiramate affects the activity of two neurotransmitters in the brain. Topiramate enhances the action of GABA, which is a neurotransmitter that acts as a natural 'nerve calming' agent.