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In 2010, the National Institutes of Health (NIH) established the Therapeutics for Rare and Neglected Diseases (TRND) program within the National Center for Advancing Translational Science (NCATS), which was created to stimulate drug discovery and development for rare and neglected tropical diseases through a collaborative model between the NIH, academic scientists, nonprofit organizations, and pharmaceutical and biotechnology companies.
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Formulated for both topical and systemic use, itraconazole preferentially inhibits fugal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis.
Results of a pharmacokinetics study suggest that itraconazole may undergo saturable metabolism with multiple dosing.
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It is used to treat three types of serious fungal infection such as blastomycosis, histoplasmosis, and aspergillosis.
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